Notable Papers: An Easier Way To Make Stem Cells?
We’ve talked about work out of the RIKEN Institute before. The work that comes out of there is clever and often unconventional. The latest work from the RIKEN that seems to have gotten a bit of attention is two recent papers from Haruko Obokata and colleagues, here and here that discuss almost inconceivably simple approaches to generating …
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Pastel Vision
Visit To Medical College of Wisconsin
ARVO 2013
Diseased Retina
Polypoidal Choroidal Vasculopathy
We had a recent case of Polypoidal Choroidal Vasculopathy here at the Moran Eye Center, imaged here as an ICG angiogram (large image here). Polypoidal Choroidal Vasculopathy is an uncommon disorder of the choroidal circulation summarized in the Ciardella et. al. paper Polypoidal Choroidal Vasculopathy. “The primary abnormality involves the choroidal circulation, and the characteristic lesion is …
Color Blindness: What Does It Look Like?
Notable Paper: Ras Pathway Inhibition Prevents Neovascularization By Repressing Endothelial Cell Sprouting
A new manuscript in the Journal of Clinical Investigation (on the cover)by Peter D. Westenskow, Toshihide Kurihara, Edith Aguilar, Elizabeth L. Scheppke, Stacey K. Moreno, Carli Wittgrove, Valentina Marchetti, Iacovos P. Michael, Sudarshan Anand, Andras Nagy, David Cheresh and Martin Friedlander at The Scripps Research Institute describes a new technique for treating aberrant growth of blood vessels in the …
Retinal connectomics: A New Era For Connectivity Analysis
Optic Nerve Head Drusen
Drusen in the retina is a common finding in aging retina, forming deposits in the retina between Bruch’s membrane and the retinal pigment epithelium. Most people over 40 start to accumulate some drusen, but increasing amounts of drusen formation can indicate pathological developments associated with age related macular degeneration, (AMD). Cristine Curcio has been chasing …
Acute Zonal Occult Outer Reinopathy (AZOOR)
This photo shows peripheral vasculitis in a patient with Acute Zonal Occult Outer Retinopathy (AZOOR). Five images were taken in each eye and composited together to show the peripheral changes taking place in the mid arterivenous phase of the fluorescein angiogram. This image was made by James Gilman of the Moran Eye Center using a 102 degree non-contact …
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Wavelengths Of Light From Our Sun
The National Optical Astronomy Observatory has assembled a high resolution image showing the spectrum of our Sun from 296 to 1300nm. Its interesting to note that visual systems on planet Earth have evolved to detect wavelengths of light given off by our sun and those wavelengths are solar specific. Other stars radiate different wavelengths, but I’d …
Interesting Paper: Gene Regulator, Onecut1 Important To Retinal Development And Integrity
This paper, Onecut1 Is Essential for Horizontal Cell Genesis and Retinal Integrity in the Journal of Neuroscience by authors Fuguo Wu, Renzhong Li, Yumiko Umino, Tadeusz J. Kaczynski, Darshan Sapkota, Shengguo Li, Mengqing Xiang, Steven J. Fliesler, David M. Sherry, Maureen Gannon, Eduardo Solessio, and Xiuqian Mu describes the gene regulator Onecut1 as being the key to healthy retinal …
Robust Segmentation based Tracking using an Adaptive Wrapper for Inducing Priors
