Notable Papers: An Easier Way To Make Stem Cells?

We’ve talked about work out of the RIKEN Institute before.  The work that comes out of there is clever and often unconventional.  The latest work from the RIKEN that seems to have gotten a bit of attention is two recent papers from Haruko Obokata and colleagues, here and here that discuss almost inconceivably simple approaches to generating …

Polypoidal Choroidal Vasculopathy

We had a recent case of Polypoidal Choroidal Vasculopathy here at the Moran Eye Center, imaged here as an ICG angiogram (large image here).  Polypoidal Choroidal Vasculopathy is an uncommon disorder of the choroidal circulation summarized in the Ciardella et. al. paper Polypoidal Choroidal Vasculopathy. “The primary abnormality involves the choroidal circulation, and the characteristic lesion is …

Notable Paper: Ras Pathway Inhibition Prevents Neovascularization By Repressing Endothelial Cell Sprouting

A new manuscript in the Journal of Clinical Investigation (on the cover)by Peter D. Westenskow, Toshihide Kurihara, Edith Aguilar, Elizabeth L. Scheppke, Stacey K. Moreno, Carli Wittgrove, Valentina Marchetti, Iacovos P. Michael, Sudarshan Anand, Andras Nagy, David Cheresh and Martin Friedlander at The Scripps Research Institute describes a new technique for treating aberrant growth of blood vessels in the …