Foveal Avascular Zone
This is normal fluorescein angiogram of a human retina showing the tunic of capillaries that surround the fovea and rather nicely illustrates the Foveal Avascular Zone (FAZ) discussed in The Simple Anatomy of The Retina. Photograph was made by James Gilman of the Moran Eye Center.
Weekend App Experiments
Looking At The Sky…
Artisan Lens
The artisan lens is an anterior chamber lens used to treat patients with high myopia. Photograph was made by James Gilman of the Moran Eye Center using sclerotic scatter illumination with a Zeiss photo slitlamp and a Nikon D-1X camera.
Ophthalmologic Care In The 1800s
CBS news has a post up with a collection of photographs from the 19th and 20th centuries of ophthalmologic care from the extensive and excellent archives of The Burns Archive, one of the largest collections of early medical photography in the world curated by Dr. Stanley B. Burns. Note: some images are potentially disturbing. …
Notable Paper: Enzymatic Properties and Regulation of the Native Isozymes of Retinal Membrane Guanylate Cyclase (RetGC) from Mouse Photoreceptors
This paper is a collaboration of Dr. Wolfgang Baehr and two experts in guanylate cyclase enzymology, Dr. Alexander Dizhoor, and Dr. Kris Palczewski representing a long standing collaboration that has generated over fifty papers going back to 1994. The results are based on animal models generated at the University of Utah and elucidate the contribution of …
The 4th of July Holiday Weekend Sans SLR
Morning Coffee
A Photographers Visit to the Moran Eye Center
A friend, renaissance man and photographer extraordinaire, Duncan Davidson visited us at the Moran Eye Center and hung out for a day of science while we performed experiments. Duncan documented some of the work we did that day in the lovely video he posted to Vimeo above. You have quite possibly seen Duncan’s work before …
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Notable Paper: Virally Delivered Channelrhodopsin-2 Safely and Effectively Restores Visual Function in Multiple Mouse Models of Blindness
This truly groundbreaking paper by M Mehdi Doroudchi, Kenneth P Greenberg, Jianwen Liu, Kimberly A Silka, Edward S Boyden, Jennifer A Lockridge, A Cyrus Arman, Ramesh Janani, Shannon E Boye, Sanford L Boye, Gabriel M Gordon, Benjamin C Matteo, Alapakkam P Sampath, William W Hauswirth and Alan Horsager demonstrates that channelrhodopsin-2, a cation channel from …
Notable Paper: UNC119 is Required for G Protein Trafficking in Sensory Neurons
Photoreceptors are specialized cells that elaborate a cilium which becomes the inner and outer segments of the photoreceptor that house photopigments (a beautiful TEM image of a photoreceptor cilium and its inner/outer segment can be seen here)…. Cilium are specialized structures that come in two flavors, motile and non-motile. Motile cilium are found in places …
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Cone Opsin Determines The Time Course of Cone Photoreceptor Degeneration in Leber Congenital Amaurosis
It is been long known that ventral and central cones degenerate more rapidly than dorsal cones in retinoid-deprived LCA (Leber’s Congenital Amaurosis) models. This paper in PNAS by Tao Zhang, Wolfgang Baehr… …and Yingbin Fu shows that SW-opsins, but not ML-opsin, aggregates to form cytoplasmic inclusions in mutant mice and transfected cells. This result explains …
Right Now: Biking In The Foothills
ARVO, 2011
