This study by Mark E. Pennesi, Keith V. Michaels, Sienna S. Magee, Anastasiya Maricle, Sean P. Davin, Anupam K. Garg, Michael J. Gale, Daniel C. Tu, Yuquan Wen, Laura R. Erker, and Peter J. Francis documents the use of SD-OCT as a robust, non-invasive method for monitoring retinal changes in vivo in rodent models of retinal degeneration. …
Pergamon Museum
Berlin Aquarium
Doctoral Dissertation Defense: Crystal Sigulinsky
Congratulations to Dr. Crystal Sigulinsky on a successful defense to her dissertation, “Defining the relationship between the homeobox gene Vsx2 and extrinsic signaling in the regulation of retinal progenitor cell properties”. Crystal did her doctoral work in Ed Levine’s laboratory here at the Moran Eye Center and has plans to go into industry.
Notable Paper: Metabolic Differentiation In The Embryonic Retina
Michalis Agathocleous, Nicola K. Love, Owen Randlett, Julia J. Harris, Jinyue Liu, Andrew J. Murray and William A. Harris have published a very interesting story on proliferating cells of the Xenopus laevis retina that documents aerobic glycolysis rather than oxidative phosphorylation. Historically, this shift in metabolism was termed the Warburg effect where it was originally described in …
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Archaeopteryx
SLC to CDG
Staring Into The Sun
Your Central Visual Field by XKCD
This little bit of visual comic brilliance comes to you by way of XKCD. Click here for the full size image from the XKCD website. XKCD is one of my all time favorite websites with a new comic posted fairly routinely. I’ve been following the author of XKCD, Randall Munroesince his very first postings on …
Notable Paper: Full-Length Axon Regeneration In The Adult Mouse Optic Nerve and Partial Recovery of Simple Visual Behaviors
Friend, Yves Sauvé sent in this paper by Silmara de Lima, Yoshiki Koriyama, Takuji Kurimoto, Julia Teixeira Oliveira, Yuqin Yin, Yiqing Li, Hui-Ya Gilbert, Michela Fagiolini, Ana Maria Blanco Martinez, and Larry Benowitz that documents regeneration of the optic nerve in the adult mouse, a potentially substantial breakthrough in therapeutic recovery of vision lost through disease or …
Notable Paper: Functional and Anatomical Remodeling in Human Retinal Detachment
This manuscript by Clairton F de Souza, Michael Kalloniatis, Philip J Polkinghorne, Charles N J McGhee and Monica L Acosta examined retinal remodeling in response to a form of retinal detachment. Rhegmatogenous retinal detachment. The authors describe the changes observed and note that retinal plasticity is acute and likely occurs quickly enough that it may explain persistent …
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Complicated Retinal Detatchment
This set of images (click the image above to enlarge) are optical coherence tomography (OCT) images of retained perfluoro-octane(PFO) droplets after repair of a complicated retinal detachment. PFO is a good surgical tool to help reattach the retina as they force sub retinal fluid out of any retinal tears and helps adhere the retina …
Notable Paper: Microglia Sculpt Postnatal Neural Circuits In An Activity And Complement-Dependent Manner
This very cool study by Dorothy P. Schafer, Emily K. Lehrman, Amanda G. Kautzman, Ryuta Koyama, Alan R. Mardinly, Ryo Yamasaki, Richard M. Ransohoff, Michael E. Greenberg, Ben A. Barres and Beth Stevens demonstrates how the immune system can participate in the circuitry of the developing mouse lateral genicular nucleus (LGN). As the immune cells of the central nervous system (CNS), microglia are constantly …
ValuJet Memorial
Your Brain Develops The Negative
Instructions: 1. Stare at the gray dot on the woman’s nose for 30 seconds (click on image for larger size). 2. Look quickly at the gray box below (or look at a plain surface like a ceiling or blank wall). 3. Blink repeatedly and quickly. What you should see is a full color representation of …