Missense variant in CST3 Exerts Recessive Effect On Susceptibility to AMD

There is an interesting paper out demonstrating that CST3 exerts a recessive effect on susceptibility to AMD.  Cystatin C is a potent inhibitor of cysteine proteinases expressed by many tissues and in the eye, it is highly expressed by the retinal pigment epithelium (RPE). The team led by Luminita Paraoan recently reported data identifying a polymorphism in the …

Bruch’s Membrane

Bruch’s membrane is a highly specialized and multi-laminar structure in our retinas that forms the basis for mediating interactions between the retinal pigment epithelium and blood flow from the choroid.  I’ve not seen many good images online, so figured this image from mouse would be a good addition showing the relationship of the basal surface …