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Retinal Connectome (RC1) completed on 9 April 2009
And we are in Wired.com

PLoS Biology March 31, 2009 :: Anderson et al.
A Computational Framework for Ultrastructural Mapping of Neural Circuitry
AUTHOR SUMMARY: Building an accurate neural network diagram of the vertebrate nervous system is a major challenge in neuroscience. Diverse groups of neurons that function together form complex patterns of connections often spanning large regions of brain tissue, with uncertain borders. Although serial-section transmission electron microscopy remains the optimal tool for fine anatomical analyses, the time and cost of the undertaking has been prohibitive. We have assembled a complete framework for ultrastructural mapping using conventional transmission electron microscopy that tremendously accelerates image analysis. This framework combines small-molecule profiling to classify cells, automated image acquisition, automated mosaic formation, automated slice-to-slice image registration, and large-scale image browsing for volume annotation. Terabyte-scale image volumes requiring decades or more to assemble manually can now be automatically built in a few months. This makes serial-section transmission electron microscopy practical for high-resolution exploration of all complex tissue systems (neural or nonneural) as well as for ultrastructural screening of genetic models.

Micron Camera PDF | Micron Mouse FA Mov | Synapse Chapter
Ignite SL 2.0 :: The Twenty Senses | Ignite SL 2.0 :: The Twenty Senses on YouTube

NIH Challenge Grants | NIH Large Scale Grants

The "100 Retina Papers You Should Read" Series : Tuesdays 10AM Marclab
What we've read so far ...
Baylor & Hodgkin 1973 J Physiol, Naka 1977 J Neurophysiol, Witkovsky & Dowling 1969 Z Zellforsch,
Marks 1965 J Physiol, Nathans 1986 Science, Spekreijse H, Wolbarsht M, Wagner H 1968 Science
Next up
ARVO break until mid-May
12 May 12 2009 Hecht, Shlaer, and Pirenne 1941 Science 93: 585-587
14 April 2009 Rushton, WAH 1972 J Physiol 220: 1-31

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