ACTIVE AWARDS
- NIH NEI RO1 EY02576-30...35, Title: Structural Neurochemistry of Retinal Circuits, PI: R Marc, Period 01 Jan 2006...31 Dec 2010, Role & Objectives: Robert E. Marc, PI (30%); The aims of this program are to (1) generate a comprehensive retinal map of synaptic connectivity steered by computational classification segmentations; (2) resolve the neurochemical identities of key interneurons; (3) resolve the scaling parameters for glutamatergic drive through the retina.
- NIH NEI RO1 EY015128-01...07, Title: Retinal Remodeling, PI: R Marc, Period: 01 July 2004...31 Dec 2011, Role & Objectives: Robert E. Marc, PI (30%); The aims of this program are to (1) Define the patterns and chronologies of remodeling in RP-like retinal degenerations; (2) Map the anomalous rewiring patterns of remodeling neurons; (3) Determine the trigger mechanisms and regulation of remodeling.
- NIH NEI P30 EY014800, Title: Core Grant for Vision Research, PI: R Marc, Period: 1 April 2005...30 Mar 2010, Role & Objectives: Robert E. Marc, PI and Director; The aims of this program are to develop comprehensive imaging, molecular biology and functional assessment resources for vision research core group of 12 NEI grant holders.
- NIH NIBIB R01 EB005832, Title: Large-scale computational reconstruction of three-dimensional neural connectivity from serial-section microscopy, PI: T Tasdizen, U Utah School of Computing. Period 01 Jul 2005...30 Jun 2009, Role & Objectives: Robert E. Marc, co-PI (8%); The goal of this program is the development of high-capacity software tools for precise, non-linear, automated image mosaicking and registration; process segmentation and tracking; texture mapping; and synapse identification using a large (>Tbyte) ultrastructural connectivity dataset from the mammalian retina.
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EDITORIAL EXPERIENCE
- 1997...2002 Associate Editor, Visual Neuroscience
- 1992 Co-editor (Mize, Marc, Sillito) Progress in Brain Research V 90
- 1991...1993 Editorial Board, Visual Neuroscience
- 1985...1992 Executive Editor, Experimental Eye Research
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ACADEMIC HONORS
- 2003...present, Mary H. Boesche Professorship, University of Utah
- 2003...2005 Research to Prevent Blindness Senior Investigator Award, University of Utah
- 1993...2001 Jules & Doris Stein Research to Prevent Blindness Professorship, University of Utah
- 1986...1993 Robert Greer Professorship, UTGSBS
- 1980, 1997, 1998 Invited Lecturer 3rd, 20th, and Final Taniguchi Symposium
- 1976 Glenn Fry Award, American Academy of Optometry
- 1972 Student Fellow, Argonne National Laboratories Conference on Photobiology
- 1967...1971 Stevens Scholar and B.Sc. Honors, University of Texas at El Paso
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PROFESSIONAL SOCIETIES
- Metabolomics Society
- Society for Neuroscience
- Association for Research in Vision and Ophthalmology
- AAAS
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ADMINISTRATIVE EXPERIENCE
- 2006... Director of Research, University of Utah Department of Ophthalmology
- 2004...2006 Associate Director of Research, University of Utah Department of Ophthalmology
- 2004...2006 Directorate, University of Utah Neuroscience Program
- 1986...2007 Ad hoc reviewer for NSF and NIH NEI
- 1994...1999 Course Director, Cellular and Molecular Neuroscience Core Course
- 1994...1996 Chair, University of Utah Neuroscience Program Curriculum Committee
- 1992... NSF Committee of Visitors (External Review of NSF Policies)
- 1991...1993 Fellowship Review Board, Fight for Sight (Research to Prevent Blindness, Inc.)
- 1992... U Texas Health Sci Ctr / Hou Planning and Budget Committee
- 1990...1992 Chair, Committee of Professors, UTGSBS UTGSBS
- 1990...1993 Academic Standards Comm (Chair, 1992-1993), UTGSBS
- 1989...1991 Cell Biology Program Planning Comm, ARVO
- 1989... Strategic Planning Committee, U Texas Health Sci Ctr / Hou
- 1988... Federal Demonstration Project Committee, U Texas Health Sci Ctr / Hou
- 1982...1986 NIH NEI Study Section, VIS A2
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TEACHING, SERVICE & STUDENTS
(Conference chairs, Invited lectures etc., not included) 31 y graduate level teaching, 1 MSc, 5 PhDs, 9 post-doctoral fellows, three current PhD students
- 2009...University of Utah Graduate Student and Postdoctoral Scholar Mentor Award
- 2005...Session Organizer on Imaging Retinal Function 9th Vision Research Conf, Ft Lauderdale
- 2002...Session Organizer on Retinal Remodeling 6th Vision Research Conf, Ft Lauderdale
- 2000...2002 Lecturer, Physiology 7910, Computational molecular phenotyping
- 1997...Co-Organizer, 3rd Great Basin Visual Science Symposium
- 1997...Organizer, Western Eye Research Conference, Snowbird
- 1994...1999 Director, Cellular / Molecular Neuroscience, Neuroscience Program Core Course
- 1994...1999 Cellular / Molecular Neuroscience: Ranked 1st lecturer all 6 years.
- 1994...1996 Vision Lectures, 1st Y Medical Students, U Utah Med Sch
- 1993...2007 Visual Neuroscience, University of Utah
- 1993...2009 Director: Visual Neuroscience, University of Utah
- 1989...The Dean's Teaching Excellence Award, UTGSBS
- 1985...1990 Dean's Teaching Excellence List, UTGSBS
- 1981...1983 Sensory Physiology Lectures, 1st Y Medical Students, U Texas Med Sch
- 1981...1991 Director: Visual Neuroscience I & II,
- 1981...1991 Visual Neuroscience II, UTGSBS, 2 lectures
- 1981...1991 Visual Neuroscience I, UTGSBS, 10 Lectures
- 1981...1991 Sensory Neuroethology, Sole lecturer, UTGSBS
- 1980...1990 Evolution of the Vertebrate Nervous System, Sole lecturer, UTGSBS
- 1978...1980 Sensory Biology, Lecturer for 1/4 of course, UTGSBS
- 1978...2007 Supervisory Committees for 35 doctoral students
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CURRENT RESEARCH
My global objectives are the development of imaging strategies and molecular probes designed to reveal cellular physiological states and large-scale neural systems reconstruction. The current focus is computational molecular phenotyping: a system of analysis based on anti-hapten molecular detection, high-density sample array fabrication, multidimensional image processing and computational pattern recognition analyses for image segmentation. I have developed a library of >60 small-molecule probes (including probes to the free states of 20 natural amino acids as well as glutathione, taurine, etc; and a set of exogenous probe molecules) to map cellular metabolic signatures, transport and channel permeation. The latter employs organic cation probes and detection to map functional glutamate signaling in the retina and brain. Applications of this technology include high-throughput phenotyping, pharmacological response assays, and cellular metabolic profiling. We have also discovered unprecedented plasticity and rewiring in the neural retina in advanced degenerative diseases; phenomena that change strategies for retinal rescue via genetic, molecular, cellular or bionic means. I have also founded a startup company, Signature Immunologics Inc, that provides a library of small molecule probes and continues to explore strategies for commercialization of anti-hapten methods. Finally, we are undertaking the largest ultrastructural neural systems reconstruction yet attempted.
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CAREER RESEARCH HIGHLIGHTS
- 2009 Complete retinal mapping ultrastructure volume completed
- 2007 Characterization of neural reprogramming processes in retinal degenerations
- 2003 Characterization of neural remodeling processes in retinal degenerations
- 2002 First comprehensive mapping of ganglion cells published
- 2000 Computational fusion of EM ultrastructure-LM molecular mapping published
- 2000 New metabolic activity mapping probes developed
- 1999 Novel channel permeation activity mapping published
- 1998 Computational molecular phenotyping of a disease process published
- 1996 Signature Immunologics Inc established
- 1995 Channel permeation activity probes developed
- 1995 First computational molecular phenotyping published
- 1990...2004 Library of >50 molecular probes developed
- 1990 Quantitative mapping of cellular glutamic acid distributions published
- 1978...1981 EM microscopic mappings of retinal inhibitory transmitter circuits published
- 1975...1977 First functional mapping of vertebrate cone mosaics published
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