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And we are in Wired.com
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| PLoS Biology March 31, 2009 :: Anderson et al. | A Computational Framework for Ultrastructural Mapping of Neural Circuitry AUTHOR SUMMARY: Building an accurate neural network diagram of the vertebrate nervous system is a major challenge in neuroscience. Diverse groups of neurons that function together form complex patterns of connections often spanning large regions of brain tissue, with uncertain borders. Although serial-section transmission electron microscopy remains the optimal tool for fine anatomical analyses, the time and cost of the undertaking has been prohibitive. We have assembled a complete framework for ultrastructural mapping using conventional transmission electron microscopy that tremendously accelerates image analysis. This framework combines small-molecule profiling to classify cells, automated image acquisition, automated mosaic formation, automated slice-to-slice image registration, and large-scale image browsing for volume annotation. Terabyte-scale image volumes requiring decades or more to assemble manually can now be automatically built in a few months. This makes serial-section transmission electron microscopy practical for high-resolution exploration of all complex tissue systems (neural or nonneural) as well as for ultrastructural screening of genetic models. |
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Synapse Chapter
| Ignite SL 2.0 :: The Twenty Senses | Ignite SL 2.0 :: The Twenty Senses on YouTube
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| The "100 Retina Papers You Should Read" Series : Tuesdays 10AM Marclab | What we've read so far ... | Baylor & Hodgkin 1973 J Physiol, Naka 1977 J Neurophysiol, Witkovsky & Dowling 1969 Z Zellforsch, Marks 1965 J Physiol, Nathans 1986 Science, Spekreijse H, Wolbarsht M, Wagner H 1968 Science Next up | ARVO break until mid-May | 12 May 12 2009 Hecht, Shlaer, and Pirenne 1941 Science 93: 585-587 | 14 April 2009 Rushton, WAH 1972 J Physiol 220: 1-31 | |
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