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 Remodeling animation (right-click or control-click and download)Large hi res MOV version: 93 Mb 500 x 427 px, 24 FPS Download Large MOV Version Small hi res MOV version: 16 Mb 300 x 256 px, 12 FPS Download Small MOV Version Small lo res MPEG-4 version: 1.7 Mb 320 x 240 px, 30 FPS Download Small MPEG Version Remodeling animation: This animation is a morph of three separate datasets spanning about 2 years in the life of a "GHL" mouse that expresses a transgenic mutant of rhodopsin on a normal rhodopsin background. The GHL rhodopsin slowly kills the rods over about a year - halfway thru the animation - it is a model of human autosomal dominant RP. After rod death, three major events transform the neural retina: (1) slow neuronal death; (2) glial and neuronal migration; (3) rewiring (not directly visible in this scheme). The colors represent mixtures of signature molecules that allows tracking key cell classes (taurine=RED, glutamine=green, glutamate=blue). Müller cells have a characteristic yellowish signature in this representation. The animation also shows the well-known invasion of the retina by the RPE (golden brown cell mass). Animation by Dr. Bryan William Jones. © BWJones 2003 |
 Flash Remodeling Cartoon (right-click or control-click and download)Flash movie SWF version: 7.3 Mb, 550 x 550 Download SWF Flash movie MOV version: 25.6 Mb, 550 x 550 Download MOV Remodeling cartoon: This animation depicts the changes that transform a generic mammalian retina through rod degeneration, cone degeneration, neurite remodeling, global remodeling and "plateau" remodeling where neural transformations are slowly disassembled by neuronal loss. NOTE: Flash STOP and PLAY buttons are disabled in Quicktime MOV file Animation by R Marc. © REM 2003 |
Remodeling diagrams: A set of static remodeling diagrams (*.tif) at full (1024 x 768) Keynote or Powerpoint resolution with LZW compression. All at 250-500 Kb and each has descriptive text. Normal → Phase 1 Remodeling Diagram (right-click or control-click and download) |
 Normal → Phase 1 Remodeling Diagram text (right-click or control-click and download) |
 Phase 1 → Phase 2 Remodeling Diagram (right-click or control-click and download) |
 Phase 2 → Early Phase 3 Remodeling Diagram (right-click or control-click and download) |
 Early Phase 3 → Late Phase 3 Remodeling Diagram (right-click or control-click and download)© REM 2004 |
 Microneuromas (right-click or control-click and download)Microneuromas: An image of GABA signals showing extensive microneuroma formation in the hrhoG degeneration model (*.tif) at full (1024 x 768) Keynote or Powerpoint resolution with LZW compression. Microneuromas are rewiring tufts of varying size: as small as 10 µm to over 200 µm. They are not visible in normal histological preps but with hi res, hi def immunocytochem, they are clearly profuse. In some rodents they are present at 10,000-30,000 / retina. That only includes the larger, more obvious ones. The double circled tuft is actually in the RPE layer, outside the retina. |
 Human_remodeling (right-click or control-click and download)Advanced remodeling in the human retina: A fully labeled multispectral image (taurine=red, glycine=green, glutathione=blue) of human RP retina in advanced stages - the patient had been completely blind for decades. Full (1024 x 768) Keynote or Powerpoint resolution with LZW compression. This tissue bears no resemblance to retina nand was drawn from a dataset spanning 19 mm of retina. All was of similar disorganization. © REM 2005 |
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