A friend of mine (and amazing landscape/nature photographer) Jim Goldstein sent me a Tweet and pointed out simmering new conjecture in the art community that Vincent Van Gogh might have been color blind, specifically a protanope. I seem to remember some discussion of this years ago, particularly given that one can rather nicely simulate both protanopia …
Berlin, Germany
Notable Paper: Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration
How photoreceptor cells go through the process of cell death has been an outstanding question. The authors of this paper by Yusuke Murakami, Hidetaka Matsumoto, Miin Roh, Jun Suzuki, Toshio Hisatomi, Yasuhiro Ikeda, Joan W. Miller, and Demetrios G. Vavvas have further defined the process and identified the receptor interacting protein kinase (RIP) pathway as a …
Sometimes, Life Throws You A Curveball…
Sunrise
Macular pigment imaging in AREDS2 participants: An ancillary study of AREDS2 subjects enrolled at the Moran Eye Center
This study by Paul S. Bernstein, Faisal Ahmed, Aihua Liu, Susan Allman, Xiaoming Sheng, Mohsen Sharifzadeh, Igor Ermakov, and Werner Gellermann in IOVS examined the macular pigment in AREDS2patients. AREDS2 is a randomized, placebo-controlled study designed to determine whether supplementation with 10 mg of lutein and 2 mg of zeaxanthin per day can slow the rate of progression …
Gemäldegalerie
Ägyptisches Museum und Papyrussammlung
The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells
This is an important issue for anyone involved in using murine models of retinal degeneration. It turns out that contamination of Rd8 mutation in the B6 mice is more wide spread than the C57BL/6N mice. Labs worldwide are going to have to reassess their data due to this mutation and all reviewers will ask about this …
Undersized Dendritic Arborizations in Retinal Ganglion Cells of the rd1 Mutant Mouse: A Paradigm of Early Onset Photoreceptor Degeneration
This paper by Devid Damiani, Elena Novelli, Francesca Mazzoni and Enrica Strettoi documents continued negative plasticity in retina by examining ganglion cells in the rd1 mouse. The rd1 mouse is one of many models of retinal degenerative disease, in this case as an autosomal recessive retinal degenerative disease. This work gets at the remodeling issue …
Notable Paper: Long-Term Characterization of Retinal Degeneration in rd1 and rd10 Mice Using Spectral Domain Optical Coherence Tomography
This study by Mark E. Pennesi, Keith V. Michaels, Sienna S. Magee, Anastasiya Maricle, Sean P. Davin, Anupam K. Garg, Michael J. Gale, Daniel C. Tu, Yuquan Wen, Laura R. Erker, and Peter J. Francis documents the use of SD-OCT as a robust, non-invasive method for monitoring retinal changes in vivo in rodent models of retinal degeneration. …
Pergamon Museum
Berlin Aquarium
Doctoral Dissertation Defense: Crystal Sigulinsky
Congratulations to Dr. Crystal Sigulinsky on a successful defense to her dissertation, “Defining the relationship between the homeobox gene Vsx2 and extrinsic signaling in the regulation of retinal progenitor cell properties”. Crystal did her doctoral work in Ed Levine’s laboratory here at the Moran Eye Center and has plans to go into industry.
Connectomics Analysis of Rod-Cone Interaction Networks
